Scientists in the UK have uncovered a genetic link between obesity-prone Labradors and humans, revealing a shared biological trait that drives overeating and weight gain.

The study, published in ‘Science’, identifies changes in a gene called DENND1B, which alters brain signals that regulate appetite. Lead researcher Dr. Eleanor Raffan from the University of Cambridge explains that this discovery highlights the biological basis of obesity risk, challenging the notion that slim individuals are simply more disciplined.

"If you have a high genetic risk of obesity, you’re prone to gaining weight unless you make a huge effort not to," Dr. Raffan said. "Those with low genetic risk just don’t have to work as hard."

The team examined the genetics of 250 Labradors, identifying DENND1B as a common factor in overweight dogs. Further analysis of human genetic data confirmed that this same gene is linked to higher body mass in people.

Prior to this study, DENND1B was not suspected to play a role in obesity. The gene interferes with a brain pathway that controls hunger and energy expenditure, essentially making individuals with this variation feel hungrier and burn fewer calories.

These findings could contribute to the development of obesity treatments in the future. However, researchers emphasise that those with this genetic predisposition—both human and canine—must work significantly harder to manage their weight.

Co-researcher Alyce McClellan added that the study underscores "the importance of fundamental brain pathways in controlling appetite and body weight."

This groundbreaking research not only sheds light on obesity’s genetic roots but also offers hope for targeted interventions, potentially leading to more effective treatments for weight management in both humans and dogs.